An EB-5 Regional Center is an organization designated by United States Citizenship and Immigration Services (USCIS) that sponsors capital investment projects for investment by EB-5 investors. The regional center can take advantage of indirect job creation which is a major advantage, since regional centers help EB-5 investors and project developers to lessen the difficulty of meeting qualifying job creation requirements under the EB-5 program rules. Any private or public economic entity that is involved with the promotion of job creation, increased domestic capital as well as improved regional productivity and increased economic growth can be a regional center.

Regional centers are best for EB-5 applicants who are more concerned with obtaining residency status rather than directly managing an investment on their own.